Calcium channel blockers eg, nifedipine , corticosteroids eg, prednisone , diuretics eg, furosemide, hydrochlorothiazide , estrogen, hormonal contraceptives eg, birth control pills , insulin, isoniazid, nicotinic acid, oral antidiabetics eg, glipizide , phenothiazines eg, chlorpromazine , phenytoin, sympathomimetics eg, albuterol, pseudoephedrine , or thyroid hormones eg, levothyroxine because the risk of high or low blood sugar may be increased amiloride, cimetidine, digoxin, gemfibrozil, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of actoplus met s side effects rifampin because it may decrease actoplus met s effectiveness, resulting in high blood sugar anticoagulants eg, warfarin because their effectiveness may be decreased or the risk of their side effects may be increased by actoplus met.
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