According to the manufacturer, since paliperidone may prolong the qt interval, it should be avoided in combination with other agents also known to have this effect, such as olanzapine.
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maintenance trials showed olanzapine to be more efficacious than placebo in the prevention of manic and depressive relapses and non-inferior to lithium or valproate.
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fasting lipid data is limited for symbyax; however, in an analysis of 5 placebo-controlled olanzapine monotherapy studies with treatment duration up to 12 weeks, olanzapine-treated patients had increases from baseline in mean fasting total cholesterol, ldl cholesterol, and triglycerides of 5.
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inhibitors of cyp1a2 could potentially inhibit olanzapine clearance.
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nevertheless, because human experience is limited, olanzapine should be used in pregnancy only if the potential benefit justifies the potential risk to the foetus.
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